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Nitrogenous bases covalently linked to a sugar with and without phosphate groups; used for synthesis, cell signaling, and as cofactors in enzymatic reactions; includes pyrimidine, purine, pyridine, flavin, pyrrolopyrimidine, and triazole varieties.
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ATP-15N5 dilithium is a 15N labeled form of Adenosine 5'-triphosphate (ATP), which is a crucial component of energy storage and metabolism in living organisms. It plays a vital role in driving metabolic pumps and functions as a coenzyme within cells. Furthermore, ATP is recognized as a significant endogenous signaling molecule involved in immunity and inflammation processes.
Is a 15N labeled ATP.
Central to energy storage and metabolism.
Drives metabolic pumps.
Functions as a coenzyme in cells.
Serves as an important endogenous signaling molecule in immunity and inflammation.
Can be used as a tracer.
Suitable as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
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Guanosine 5'-triphosphate trisodium salt hydrate activates signal transducing G proteins and functions as an energy-rich precursor for mononucleotide units in the enzymatic biosynthesis of DNA and RNA. This product is intended for research use only.
Activates signal transducing G proteins
Precursor for DNA and RNA biosynthesis
Solid, white to off-white physical form
Store at -20°C under nitrogen, away from moisture
When in solvent, stable at -80°C for 6 months and -20°C for 1 month
Soluble in H2O at ≥ 150 mg/mL
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Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. It promotes myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. This product holds promise for research in biosynthesis and skeletal muscle regeneration.
G protein signaling activator
High-energy precursor in biosynthesis of nucleotide units in DNA and RNA
Promotes myogenic cell differentiation
Induces release of exosomes from human myogenic precursor cells
Suitable for research in biosynthesis
Suitable for research in skeletal muscle regeneration
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β-Nicotinamide mononucleotide, reduced form disodium (NMNH) is the reduced disodium salt of nicotinamide mononucleotide supplied for research use in studies of NAD+ metabolism. It is provided as a powder with available analytical data for identity and purity and recommended cold, light-protected storage.
Chemical formula: C11H15N2Na2O8P.
Molecular weight: 380.20 g/mol.
CAS number: 108347-85-9.
Purity: 99.6% by HPLC.
Recommended storage: protect from light, store under nitrogen at -20°C; in solution store at -80°C for long term.
Analytical data available: COA, H NMR, C NMR, RP-HPLC, MS.
Typical pack sizes: 1 mg, 5 mg, 10 mg.
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β-Nicotinamide mononucleotide, reduced form (disodium) is the reduced form of β-nicotinamide mononucleotide (NMNH), an endogenous NAD+ precursor used in biochemical and cellular research. The disodium salt is supplied as a solid and is characterized for identity and purity.
Provides the reduced NMN (NMNH) disodium salt for NAD+ metabolism studies.
High purity suitable for analytical and cellular applications.
Solid form with light yellow to yellow appearance.
Storage: -20°C for solid; in solvent: -80°C up to 6 months or -20°C up to 1 month.
Characterized by HPLC, 1H NMR, and MS to confirm identity.
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MAb VU-4H5 reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. The dominant epitope of MAb VU4H5 is APDTR as established with 'epitope fingerprinting'. VU-4H5 preferentially binds to under-glycosylated 'tumor' MUC1. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 amino acids tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is upregulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
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Adenosine is a purine nucleoside base which is the precursor of adenosine triphosphate or ATP and is utilized thoroughly throughout the entire body in general metabolism. Extracellular adenosine acts as a local modulator with a generally cytoprotective function in the body. Its effects on tissue protection and repair fall into four categories increasing the ratio of oxygen supply to demand protecting against ischaemic damage by cell conditioning triggering anti-inflammatory responses and the promotion of angiogenesis.
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